SCIENTIFIC PUBLICATIONS
Alpha-1 antitrypsin inhibits pertussis toxin
Pertussis (whooping cough) is a vaccine-preventable but re-emerging, highly infectious respiratory disease caused by...
Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans
Candida albicans infections are a global health thread and challenge healthcare environments due to acquired...
Cm-p5, a molluscan-derived antifungal peptide exerts its activity by a membrane surface covering in a non-penetrating mode
Amidst the health crisis caused by the rise of multi-resistant pathogenic microorganisms, Antimicrobial Peptides...
Insights into the Adsorption Mechanisms of the Antimicrobial Peptide CIDEM-501 on Membrane Models
CIDEM-501 is a hybrid antimicrobial peptide rationally designed based on the structure of panusin and panulirin...
Integrating Taxonomic and Chemical Diversity of Mangrove-Associated Ascomycetes to Discover or Repurpose Bioactive Natural Products
Natural product reisolation is a bottleneck when discovering new bioactive chemical entities from nature. To overcome...
Advancing Multicomponent Strategies to Macrobicyclic Peptides
Macrocyclization of peptides is typically used to fix specific bioactive conformations and improve their...
A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2...
Development of a StIW111C-based bioresponsive pore-forming conjugate for permeabilizing the endosomal membrane
In this research, Escalona-Rodríguez and collaborators explore a non-viral strategy to deliver therapeutic genes into...
Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors
In this article, Subbarayan et al. evaluate how the ACE2 receptor, used by SARS-CoV-2 to enter cells, affects immune...
Diversification of a Novel α-Galactosyl Ceramide Hotspot Boosts the Adjuvant Properties in Parenteral and Mucosal Vaccines
The development of potent adjuvants is an important step for improving the performance of subunit vaccines. CD1d...
Comparative Immune Response after Vaccination with SOBERANA® 02 and SOBERANA® plus Heterologous Scheme and Natural Infection in Young Children
(1) Background: In children, SARS-CoV-2 infection is mostly accompanied by mild COVID19 symptoms. However, multisystem...
Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action
Whooping cough is a severe childhood disease, caused by the bacterium Bordetella pertussis, which releases pertussis...
Shared Challenges, Shared Responsibilities: Lessons Learnt for EU-LAC Cooperation in Global Health
This policy brief examines the lessons learned from the COVID-19 pandemic and the urgent need to strengthen...
Desafíos Compartidos, Responsabilidades Comunes: Lecciones Aprendidas para la Cooperación UE-ALC en Salud Global
Este Informe de Políticas es el resultado de los diálogos mantenidos durante el Simposio Internacional “Colaborando...
The social determinants of maternal and congenital syphilis at the Colombia-Venezuela border: A qualitative study of twenty mothers of newborns with congenital syphilis
Humanitarian crises and resulting out-migration have created contexts in which treatable diseases such as syphilis...
Shock y política pública: determinantes político-institucionales de la vacunación contra COVID-19 en Centroamérica (Shock and public policy: political and institutional determinants of COVID-19 vaccination in Central America)
The COVID-19 pandemic, as a shock scenario, provided an opportunity to study the performance of the same policy...
Evolución histórica del concepto de comunidad y su relación con la salud pública (Historical evolution of the concept of community and its relationship to public health)
Introduction: The clearest origin of the term community can be traced back to the late 19th century, in the political...
La participación popular como una alternativa para lograr la mejor adherencia terapéutica en el VIH/SIDA+ (Popular participation as an alternative for achieving better therapeutic adherence in HIV/AIDS+)
Human Immunodeficiency Virus (HIV) infection is currently a public health problem for the world. The aim of this...
Epidemiological, virological and clinical characterization of a Dengue/Zika outbreak in the Caribbean region of Costa Rica 2017–2018
The increase in incidence and geographical expansion of viruses transmitted by the Aedes mosquitoes, such as dengue...
A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles
SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain...
In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors
Despite vaccines are the main strategy to control the ongoing global COVID-19 pandemic, their effectiveness could not...
Improved Access to Potent Anticancer Tubulysins and Linker-Functionalized Payloads Via an All-On-Resin Strategy
Tubulysins are among the most recent antimitotic compounds to enter into antibody/peptide-drug conjugate (ADC/PDC)...
Serologic Evidence for Early SARS–CoV-2 Circulation in Lima, Peru, 2020
During early 2021, Peru had the highest COVID-19–associated per-capita mortality rate. Socioeconomic inequality,...
The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen Pseudomonas aeruginosa with Low Cytotoxicity
The diminishing portfolio of mankind’s available antibiotics urges science to develop novel potent drugs. Here, we...