SCIENTIFIC PUBLICATIONS
Exploration of the Tertiary Amide Chemical Space of Dolastatin 15 Analogs Reveals New Insights into the Structure–Anticancer Activity Relationship
Dolastatins are a class of naturally occurring antimitotic peptides that have inspired the development of some of the...
Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
Introduction: Invasive candidiasis is a global public health problem as it poses a significant threat in...
Multicomponent Functionalization of the Octreotide Peptide Macrocyclic Scaffold
The replacement of the disulfide bridge by other types of side chain linkages has been a continuous endeavor in the...
Improved Access to Potent Anticancer Tubulysins and Linker-Functionalized Payloads Via an All-On-Resin Strategy
Tubulysins are among the most recent antimitotic compounds to enter into antibody/peptide-drug conjugate (ADC/PDC)...
The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen Pseudomonas aeruginosa with Low Cytotoxicity
The diminishing portfolio of mankind’s available antibiotics urges science to develop novel potent drugs. Here, we...
Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide
Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer...
Epidemiological, virological and clinical characterization of a Dengue/Zika outbreak in the Caribbean region of Costa Rica 2017–2018
The increase in incidence and geographical expansion of viruses transmitted by the Aedes mosquitoes, such as dengue...
Ancient evolutionary origins of hepatitis E virus in rodents
Hepatitis E virus (HEV; family Hepeviridae) infections cause >40,000 human deaths annually. Zoonotic infections...
Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats
First isolated from neotropical fruit bats in Trinidad in 1956, Tacaribe virus (TCRV) has rarely been detected since....
Socioeconomic determinants potentially underlying differential global SARS-CoV-2 testing capacity: an ecological study
This study, conducted by Dr. Andrés Moreira-Soto, Dr. Jan Felix Drexler (Charité - Universitätsmedizin Berlin) and...
Experimental infection of Artibeus lituratus bats and no detection of Zika virus in neotropical bats from French Guiana, Peru, and Costa Rica suggests a limited role of bats in Zika transmission
Bats are important natural reservoir hosts of a diverse range of viruses that can be transmitted to humans and have...
Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals
Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two...
Effect of O-Acetylation on the Antigenicity and Glycoconjugate Immunogenicity of the Streptococcus Pneumoniae Serotype 7F Capsular Polysaccharide
Streptococcus pneumoniae is a bacterial pathogen causing diseases as severe as pneumonia, sepsis and meningitis. Most...
A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles
SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain...
In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors
Despite vaccines are the main strategy to control the ongoing global COVID-19 pandemic, their effectiveness could not...
Serologic Evidence for Early SARS–CoV-2 Circulation in Lima, Peru, 2020
During early 2021, Peru had the highest COVID-19–associated per-capita mortality rate. Socioeconomic inequality,...
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers
In this article, Subbarayan et al. analyze the role of the TMPRSS2 protein, which helps SARS-CoV-2 enter cells, in...
Prof. Dr. Bert Hoffmann outlines major trends shaping Latin America in 2026
A new policy brief from GIGA by Bert Hoffmann, a member of the GLACIER Steering Committee, offers a forward-looking...
Gemeinsam gegen Pandemien (Working together against pandemics)
The aim is to improve the research infrastructure in Latin America, with a particular focus on producing...
After the protests and the pandemic: reassessing the international profile of Post-Castro Cuba
As Cuba enters 2022, economic crisis and social tensions loom large. The paper reviews the external difficulties that...
Institutional reform and social policies in post-covid Cuba: an agenda for cooperation
Cuba and the European signed the Political Dialogue and Cooperation Agreement (PDCA) in December 2016. In many ways it...
Shared Challenges, Shared Responsibilities: Lessons Learnt for EU-LAC Cooperation in Global Health
This policy brief examines the lessons learned from the COVID-19 pandemic and the urgent need to strengthen...
Prof. Dr. Bert Hoffmann outlines major trends shaping Latin America in 2026
A new policy brief from GIGA by Bert Hoffmann, a member of the GLACIER Steering Committee, offers a forward-looking...
Exploration of the Tertiary Amide Chemical Space of Dolastatin 15 Analogs Reveals New Insights into the Structure–Anticancer Activity Relationship
Dolastatins are a class of naturally occurring antimitotic peptides that have inspired the development of some of the...
Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
Introduction: Invasive candidiasis is a global public health problem as it poses a significant threat in...
Multicomponent Functionalization of the Octreotide Peptide Macrocyclic Scaffold
The replacement of the disulfide bridge by other types of side chain linkages has been a continuous endeavor in the...
Effect of O-Acetylation on the Antigenicity and Glycoconjugate Immunogenicity of the Streptococcus Pneumoniae Serotype 7F Capsular Polysaccharide
Streptococcus pneumoniae is a bacterial pathogen causing diseases as severe as pneumonia, sepsis and meningitis. Most...
Epidemiological, virological and clinical characterization of a Dengue/Zika outbreak in the Caribbean region of Costa Rica 2017–2018
The increase in incidence and geographical expansion of viruses transmitted by the Aedes mosquitoes, such as dengue...