GLACIER PROJECTS
Analysis of humoral and cellular immune responses signature in subjects boosted with
SOBERANA® vaccines against Omicron variant of concern
Lead researchers:
Dr. Ilianet Palmero Álvarez (Finlay Institute of Vaccines)
Leading institution: Finlay Institute of Vaccines
Partner institution: Martin Luther University – Halle Wittemberg
Duration: 2024 –
Avances en Tecnologías de Bioconjugación y Formulación para el Desarrollo de Vacunas Preventivas
(Advances in Bioconjugation and Formulation Technologies for the Development of Preventive Vaccines)
Lead researchers:
Dr. Daniel García Rivera (University of Havana)
Contact: dgr@fq.uh.cu
Prof. Annemieke Madder (University of Gent, Belgium)
Leading institution: University of Havana
Partner institution: Finlay Institute of Vaccines
Duration: 2 years (2022 – 2024)
Desarrollo de candidatos vacunales contra SARS-COV2 basados en las plataformas tecnológicas del Instituto Finlay de Vacunas
(Development of vaccine candidates against SARS-COV2 based on the technological platforms of the Finlay Vaccine Institute)
Project coordinator: Dr. Dagmar García Rivera (Finlay Vaccine Institute)
Contact: dagarcia@finlay.edu.cu
Leading institutions: Finlay Vaccine Institute & OSDE-Biocubafarma
Participating entities: Joint Chemical and Biomolecular Synthesis Laboratory. Faculty of Chemistry, Center for Molecular Immunology, National Center for Biopreparations and Pedro Kouri Institute of Tropical Medicine.
Duration: 3 years (2020 – 2023)
History of infectious disesase control in Cuba, from Poliomyelitis (1962) in to COVID-19 (2020-23)
Lead researcher: Dr. Enrique Beldarraín Chaple
Leading institution: University of Havana
Partner institution: University of Gießen
Síntesis Química de Ingredientes Farmacéuticos Activos
(Chemical Synthesis of Active Pharmaceutical Ingredients)
Lead researchers:
Dr. Daniel García Rivera (University of Havana)
Contact: dgr@fq.uh.cu
Dr. Julieta Coro Bermello (University of Havana)
Contact: julieta@fq.uh.cu
Leading institution: University of Havana
Partner institutions: Center for Research and Development of Medicines (CIDEM) and the University of Havana Foundation.
Duration: 3 years (2022 – 2024)
Síntesis química de peptidomiméticos antitumorales y obtención de conjugados a anticuerpos monoclonales para terapia del cáncer
(Chemical synthesis of antitumor peptidomimetics and obtainment of conjugates to monoclonal antibodies for cancer therapy)
Lead researchers:
Dr. Daniel García Rivera (University of Havana)
Contact: dgr@fq.uh.cu.
Dr. Janoi Chang Calderón (BioCubaFarma)
Contact: janoi@cim.sld.cu
Leading institution: University of Havana
Partner institutions: Centre for Molecular Immunology, BioCubaFarma
Duration: 5 years (2019 – 2023)
Síntesis química y novedosos métodos de conjugación para la obtención de biomoléculas para vacunas preventivas
(Chemical synthesis and novel conjugation methods to obtain biomolecules for preventive vaccines)
Lead researcher: Dr. Daniel García Rivera
Contact: dgr@fq.uh.cu
Project coordinator: Dr. Dagmar García Rivera
Leading institutions: Finlay Vaccine Institute & University of Havana
Duration: 5 years (2019 – 2023)
Soberana’s vaccines generates T-cell response after complete scheme and boosting, and induces long-lasting immune memory
Lead researcher: Dr. Laura Rodríguez Noda
Leading institutions: Finlay Vaccine Institute
Partner institution: Martin Luther University – Halle Wittemberg
Duration: 2022 –
Vulnerabilidad del estado de Yucatán a la aparición de Enfermedades Infecciosas Emergentes (EIE) con potencial epidémico
(Vulnerability of the state of Yucatán to the outbreak of Emerging Infectious Diseases [EID] with epidemic potential)
Posdoctoral student: Dr. María Antonieta Moreno
Contact: moreno.mantonieta@gmail.com
Cloning, expression, purification and characterization of variants of a Dengue virus capsid protein for the usage as immunostimulative vaccine adjuvant
PhD student: Osmany José Díaz Bravo
GLACIER stay: Leibniz Institute of Plant Biochemistry (IPB)
Design and implementation of an integrated GLACIER database (virtual repository) for the transinstitutional/transnational knowledge exchange for Bioactives and metadata
PhD student: Víctor Manuel Cardentey Fundora
GLACIER stay: Leibniz Institute of Plant Biochemistry (IPB)
Development of a novel synthetic methodology for the covalent modifcation of bioactive peptides and the creation of cleavable peptide-drug conjugates
PhD student: Javiel Fernández Marrero
GLACIER stay: Leibniz Institute of Plant Biochemistry (IPB)
Identification and evaluation of novel antimicrobial peptides (AMP) from marine invertebrates
PhD student: Ernesto Martell Huguet
GLACIER stay: University of Ulm
Molecular analysis of primate samples coming from Mexico, Costa Rica and Guatemala. Screening for identifcation of several RNA (Paramyxovirus, Alphavirus, Flavivirus, Coronavirus) and DNA (Parvovirus, Bocavirus, Erythroparvovirus) viruses using PCR analysis
PhD student: María del Carmen Villalobos Segura
GLACIER stay: Charité – Universitätsmedizin Berlin
Multiplicator: Virus infection variation in the only non-human primate species (Ateles geoffroyi) in El Salvador using a landscape approach
PhD student: Melissa Rodríguez
GLACIER stay: Charité – Universitätsmedizin Berlin
Prevalence of bacterial pathogens, such as Actinobacillus pleuropneumoniae, in fattening pigs: Identification, differentiation and antibiotic susceptibility testing.
Performance of diagnostic methods (bronchoalveolar lavage, necropsy) for sampling pigs suffering from infections with Glaesserella parasuis and Actinobacillus pleuropneumoniae
PhD students: Gloriana Castillo Badilla
GLACIER stay: TiHo
The mechanism of action of a lobster-derived antimicrobial peptide (AMP CIDEm-501) and the structural and thermodynamic contributions of individual residues to ots anibacterial activity and its membrane interaction. Structural optimization of AMPs towards a clinical application for treatment of multidrug-resistant bacteria and
fungi using biophysical and “in silico” experiments/approaches
PhD student: Daniel Alpízar Pedraza
GLACIER stay: University of Ulm
Identification of genes and genetic structural variants (SV) associated
with chickens’ resistance to amyloid arthropathy
PhD student: Carolina Sancho Blanco
GLACIER stay: TiHo
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PhD student: Xenia Dahlen
GLACIER stay: Martin Luther University – Halle-Wittemberg
Novel non-viral delivery systems for the transfection with microRNAs and their impact on cytotoxic cell immune response against tumors
PhD student: Felipe Adonis Escalona Rodríguez
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Evelyn García Oceguera
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Nuris Liem Herrera Marrero
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Ann-Kathrin Kissman
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Ingrid Martínez Aldino
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Osvaldo Méndez Díaz
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Valeria Morales
GLACIER stay: Martin Luther University – Halle-Wittemberg
Phenotype of specific T-cells populations in subjects vaccinated with Soberana 01, Soberana 02 and Soberana Plus vaccines
PhD student: Rocmira Pérez Nicado
GLACIER stay: Martin Luther University – Halle-Wittemberg
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PhD student: Darielys Santana Mederos
GLACIER stay: Martin Luther University – Halle-Wittemberg